PuSH - Publication Server of Helmholtz Zentrum München: Pharmacokinetic interaction between 1,3-butadiene and styrene in Sprague-Dawley rats.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Laib, R.J. ; Tucholski, M. ; Filser, J.G. ; Csanády, G.A.

Pharmacokinetic interaction between 1,3-butadiene and styrene in Sprague-Dawley rats.

Arch. Toxicol. 66, 310-314 (1992)

DOI

PMC

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

Gas uptake studies were carried out to evaluate kinetic interactions between 1,3-butadiene and styrene in Sprague-Dawley rats. The animals were co-exposed by inhalation to a mixture of 1.3-butadiene between 20 and 6000 ppm (v/v) and styrene between 0 and 500 ppm. The data demonstrate that metabolism of 1,3-butadiene was partially inhibited by styrene. The inhibition was competitive at atmospheric concentrations of styrene up to 90 ppm. Higher concentrations of styrene resulted in a small additional inhibition only. The apparent Michaelis-Menten constant for 1,3-butadiene, related to the average concentration in the organism of the animals, was K(mapp) = 1.17 ± 0.37 (μmol/l of tissue) and the corresponding atmospheric concentration at steady state was 560 ppm. The inhibition constant of styrene was found to be K(i) = 0.23 ± 0.30 (μmol/l of tissue). The maximal metabolic rate for 1,3-butadiene was 230 ± 10 (μ/kg/h).

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

0.000