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Hoffmann-Fezer, G. ; Thum, J. ; Ackley, C.D.* ; Herbold, M. ; Mysliwietz, J. ; Thefeld, S. ; Hartmann, K.I.* ; Kraft, W.*

Decline in CD4+ cell numbers in cats with naturally acquired feline immunodeficiency virus infection.

J. Virol. 66, 1484-1488 (1992)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
T-cell subsets were studied by fluorescence-activated cell sorter analysis in 57 feline immunodeficiency virus (FIV)-seropositive cats with naturally acquired FIV infection to see whether CD4+-CD8+ alterations were comparable to those observed in human immunodeficiency virus-infected patients. CD4+ values were decreased and CD8+ values were increased. The CD4+/CD8+ ratio was reduced to 1.6, compared with 3.3 in 33 FIV-seronegative control cats. Variance analysis of data showed a significant influence of FIV seroposilivity, sex, and spaying of female cats on CD4+ values. CD8+ values were significantly influenced by FIV seropositivity, age, and breed. These findings indicate a similarity between FIV and human immunodeficiency virus infections, as far as alterations of T-cell subsets are concerned.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0022-538X
e-ISSN 1098-5514
Journal Journal of Virology
Quellenangaben Volume: 66, Issue: 3, Pages: 1484-1488 Article Number: , Supplement: ,
Publisher American Society for Microbiology (ASM)
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institut für Immunologie