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Decline in CD4+ cell numbers in cats with naturally acquired feline immunodeficiency virus infection.
J. Virol. 66, 1484-1488 (1992)
T-cell subsets were studied by fluorescence-activated cell sorter analysis in 57 feline immunodeficiency virus (FIV)-seropositive cats with naturally acquired FIV infection to see whether CD4+-CD8+ alterations were comparable to those observed in human immunodeficiency virus-infected patients. CD4+ values were decreased and CD8+ values were increased. The CD4+/CD8+ ratio was reduced to 1.6, compared with 3.3 in 33 FIV-seronegative control cats. Variance analysis of data showed a significant influence of FIV seroposilivity, sex, and spaying of female cats on CD4+ values. CD8+ values were significantly influenced by FIV seropositivity, age, and breed. These findings indicate a similarity between FIV and human immunodeficiency virus infections, as far as alterations of T-cell subsets are concerned.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
Publication Year
1992
HGF-reported in Year
1992
ISSN (print) / ISBN
0022-538X
e-ISSN
1098-5514
Journal
Journal of Virology
Quellenangaben
Volume: 66,
Issue: 3,
Pages: 1484-1488
Publisher
American Society for Microbiology (ASM)
Reviewing status
Peer reviewed
Institute(s)
Institut für Immunologie
Scopus ID
0026561503
PubMed ID
1310760
Erfassungsdatum
1992-12-31