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Recent progress in unraveling central nervous system processing of itch sensation.
World Allergy Organiz. J. 10, 168-173 (2008)
Itch is the major symptom of many allergic or inflammatory skin diseases, yet it is still difficult to measure objectively. This article shows and updates the development and approaches of central nervous system investigation of itch.Human neuroimaging studies on the physiology and pathophysiology of itch sensation have been hampered by the lack of a reproducible "on-off" stimulus. Short-term alternating temperature modulation of histamine-induced itch has recently been shown to provide on-off characteristics.Recent studies with functional magnetic resonance imaging demonstrate that itch sensation in healthy volunteers is processed by a network of brain regions contributing to the encoding of sensory, emotional, attentional, evaluative, and motivational aspects of itch.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
itch; cerebral processing; neuroimaging; histamine
e-ISSN
1939-4551
Quellenangaben
Volume: 10,
Pages: 168-173
Publisher
BioMed Central
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
CCG Environmental Dermatology and Allergology (ILBD-KAU)
Institute of Epidemiology (EPI)
Institute of Epidemiology (EPI)