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Open Access Green as soon as Postprint is submitted to ZB.
2-deoxy-d-glucose inhibits rejoining of radiation-induced DNA double-Strand breaks in yeast.
Int. J. Radiat. Biol. 61, 185-190 (1992)
Effects of 2-deoxy-d-glucose (2-DG) on radiation-induced DNA double-strand breaks (dsb) have been studied under non-growth conditions in a respiratory-deficient strain of the yeast Saccharomyces cerevisiae. Velocity sedimentation in neutral sucrose gradients was used to measure DNA dsb. Addition of 2-DG to the liquid-holding medium (67 mm phosphate buffer, pH 5, 30°C) at an equimolar concentration with glucose (50 mm) reduced the rate and extent of dsb rejoining. The inhibition of rejoining mediated by 2-DG is reversible for the majority-but not all-of the radiation-induced dsb.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0955-3002
e-ISSN
1362-3095
Quellenangaben
Volume: 61,
Issue: 2,
Pages: 185-190
Publisher
Informa Healthcare
Reviewing status
Peer reviewed
Institute(s)
Abteilung Biophysikalische Strahlenforschung