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Open Access Green as soon as Postprint is submitted to ZB.
The vitamin D slant on allergy.
Pediatr. Allergy Immunol. 17, 477-483 (2006)
Oral vitamin D supplementation has been introduced into modern medicine to prevent rickets without the knowledge that this may have profound immunological consequences. The main vitamin D metabolite calcitriol suppresses dendritic cell maturation and consecutive Th(1) cell development, which has independently described as a key mechanism of allergy development. Animal studies and epidemiological surveys now provide a first link of early vitamin D supplementation and later allergy where several vitamin D regulated genes seem to be involved. A randomized clinical trial of vitamin D supplementation could be a further step to follow up the vitamin hypothesis.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
asthma; rhinitis; children; cholecalciferol; side effects; rickets
ISSN (print) / ISBN
0905-6157
e-ISSN
1399-3038
Journal
Pediatric Allergy and Immunology
Quellenangaben
Volume: 17,
Issue: 7,
Pages: 477-483
Publisher
Wiley
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)