PuSH - Publication Server of Helmholtz Zentrum München: Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept.

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Ahlborg, U.G.* ; Brouwer, A.* ; Fingerhut, M.A.* ; Jacobson, J.L.* ; Jacobson, S.W.* ; Kennedy, S.W.* ; Kettrup, A. ; Koeman, J.H.* ; Poiger, H.* ; Rappe, C.* ; Safe, S.H.* ; Seegal, R.F.* ; Tuomisto, J.* ; Van Den Berg, M.D.*

Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept.

Eur. J. Pharmacol. 228, 179-199 (1992)

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A scientific evaluation was made of the mechanisms of action of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls. Distinction is made between the aryl-hydrocarbon (Ah) receptor-mediated and non-Ah receptor-mediated toxic responses. Special attention is paid to the applicability of the toxic equivalency factor (TEF) concept.

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