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Open Access Green as soon as Postprint is submitted to ZB.
Production of monodisperse, fluorescently and radioactively labelled aerosol particles.
J. Aerosol Sci. 23, 181-184 (1992)
To compare the initial anatomic sites of particle deposition with the resultant particle clearance kinetics in the lungs, it is desirable to have particles that have both radioactive and fluorescent labels. The radioactivity allows for analysis of in vivo retention by gamma camera; the fluorescence allows for analysis of post mortem lung tissue samples by fluorescence microscopy. We made solid monodisperse carnauba wax particles labelled with 99mTc and either coumarin 1 (a fluorescent blue dye) or coumarin 6 (a fluorescent yellow dye) using an evaporation-condensation aerosol generator. Particles could be made between 1 and 4 μm and at number concentrations of 106 to 107 cm-3. The solid particles remained stable in the lungs for 3 days, and the radioactive and fluorescent labels appeared to remain with the particles. The fluorescent label was homogeneous throughout the matrix.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
99mtc-radioactive Label ; Camauba Wax Particle ; Double-labelled Monodisperse Aerosol Particles ; Fluorescent Label
ISSN (print) / ISBN
0021-8502
e-ISSN
1879-1964
Journal
Journal of Aerosol Science
Quellenangaben
Volume: 23,
Issue: SUPPL. 1,
Pages: 181-184
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institut für Inhalationsbiologie