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Dalke, C. ; Andrae, U.

Propane 2-nitronate is more rapidly denitrified and is more genotoxic than 2-nitropropane in cultured rat hepatoma cells.

Toxicol. Lett. 61, 149-157 (1992)
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Open Access Green as soon as Postprint is submitted to ZB.
We have investigated the importance of nitronate formation from 2-nitropropane (2-NP) for the oxidative metabolism and the genotoxicity of 2-NP in 2sFou rat hepatoma cells. Treatment of the cells with 2-NP for up to 3 h resulted in the time-dependent appearance of nitrite in the culture medium and in a weak induction of DNA repair synthesis. Both nitrite formation and repair induction were markedly enhanced in cells exposed to the anionic form of 2-NP, propane 2-nitronate. These observations suggest that propane 2-nitronate, rather than 2-NP itself, is oxidized by the liver cells to yield a DNA-damaging product. The results also indicate that the nitro/nitronate equilibration in intact liver cells is slow, suggesting that nitronate formation represents the rate-limiting step in the metabolic activation of 2-NP.
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Publication type Article: Journal article
Document type Scientific Article
Keywords 2-nitropropane ; Denitrification ; Genotoxicity ; Liver ; Nitrite ; Propane 2-nitronate
Language english
Publication Year 1992
HGF-reported in Year 0
ISSN (print) / ISBN 0378-4274
e-ISSN 1879-3169
Journal Toxicology Letters
Quellenangaben Volume: 61, Issue: 2-3, Pages: 149-157 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Reviewing status Peer reviewed
Institute(s) Institut für Toxikologie
DOI 10.1016/0378-4274(92)90141-6
Scopus ID 0026750790
Erfassungsdatum 1992-12-31
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