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Open Access Green as soon as Postprint is submitted to ZB.
Interspecies comparison of phagolysosomal ph in alveolar macrophages.
Inhal. Toxicol. 3, 91-100 (1991)
Differences in the translocation of dissolved particle mass from the lungs to the blood were found in a recent large interspecies comparison of long-term lung clearance after inhalation of uniform 57Co3O4 particles. Since the particles were dissolved most prominently in phagolysosornes of alveolar macrophages, the differences may have been due to differences in pH in these vacuoles. The phagolysosomal pH was measured in alveolar macrophages obtained by bronchoalveolar lavage from baboons, dogs, guinea pigs, and rabbits using fluorescein-labeled amorphous silica particles as a probe. In the alveolar macrophages from the 4 species pH was on average 4.8 or 4.9 with small variations among and within animals. The results indicate that it is unlikely that differences in phagolysosomal pH are responsible for the differences in translocation observed previously.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0895-8378
e-ISSN
1091-7691
Journal
Inhalation Toxicology
Quellenangaben
Volume: 3,
Issue: 1,
Pages: 91-100
Publisher
Informa Healthcare
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institut für Inhalationsbiologie