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Open Access Green as soon as Postprint is submitted to ZB.
Low incidence of transplant-related complications in patients with chronic release of tumor necrosis factor-alpha before admission to bone marrow transplantation: A clinical correlate of cytokine desensitization?.
Pathobiology 59, 171-175 (1991)
To investigate the role of tumor necrosis factor-α (TNF-α) released by activated macrophages, sequential serum samples of 120 patients undergoing bone marrow transplantation (BMT) were analyzed by enzyme-linked immunosorbent assay. De novo increases in serum TNF-α levels were correlated with the development of acute endothelial complications as well as acute graft-versus-host disease. In addition, the analysis of time courses revealed a different capacity of TNF-α regulation at various phases of BMT. While patients with acute TNF-α release in the first 2 weeks of BMT had a significantly enhanced incidence of complications, a subgroup of 9 patients with chronic asymptomatic release of TNF-α before admission to BMT was observed. These patients were protected from complications in the course of the first 6 months of BMT. Our observations indicate the occurrence of desensitization for TNF-α, as it is also reported after repeated injections of TNF-α or endotoxin in experimental models.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Bone Marrow Transplantation ; Endothelial Complications ; Graft-versus-host Disease ; Macrophages ; Tumor Necrosis Factor-α
ISSN (print) / ISBN
1015-2008
e-ISSN
1423-0291
Journal
Pathobiology
Quellenangaben
Volume: 59,
Issue: 3,
Pages: 171-175
Publisher
Karger
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institut für Klinische Hämatologie