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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals.
EMBO J. 22, 1811-1823 (2003)
Fibroblast growth factors (FGFs) are signaling molecules of the isthmic organizer, which regulates development of the midbrain and cerebellum. Tissue‐specific inactivation of one of the FGF receptor (FGFR) genes, Fgfr1, in the midbrain and rhombomere 1 of the hindbrain of mouse embryos results in deletion of the inferior colliculi in the posterior midbrain and vermis of the cerebellum. Analyses of both midbrain–hindbrain and midbrain‐specific Fgfr1 mutants suggest that after establishment of the isthmic organizer, FGFR1 is needed for continued response to the isthmic signals, and that it has direct functions on both sides of the organizer. In addition, FGFR1 appears to modify cell adhesion properties critical for maintaining a coherent organizing center. This may be achieved by regulating expression of specific cell‐adhesion molecules at the midbrain–hindbrain border.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
cerebellum; Cre recombianse; development; FGF; isthmic organizer; midbrain
ISSN (print) / ISBN
0261-4189
e-ISSN
1460-2075
Journal
EMBO Journal, The
Quellenangaben
Volume: 22,
Issue: 8,
Pages: 1811-1823
Publisher
Wiley
Publishing Place
Heidelberg, Germany
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)