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Open Access Green as soon as Postprint is submitted to ZB.
Control of pteridine biosynthesis in the natural killer-like cell line YT.
Biochem. Biophys. Res. Commun. 176, 1430-1436 (1991)
The natural killer-like cell line YT constitutively expresses GTP-cyclohydrolase activity whereas 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase are absent. The product, dihydroneopterin triphosphate, is dephosphorylated and oxidized causing neopterin to accumulate in the cells. The activities of the H 4biopterin synthesizing enzymes are not controlled by IFN-γ or the synergistic action of both IFN-γ and IL-2 as has been shown for monocytes/macrophages (Huber C. et al. (1984) J. Exp. Med. 160, 310) and CD4 + T cells, respectively (Ziegler I. et al. (1990) J. Biol. Chem. 265, 17026). Sepiapterin reductase specifically is induced by incubation of the cells with sepiapterin, leaving GTP-cyclohydrolase, 6-pyruvoyltetrahydropterin synthase and other enzymes related to pteridine metabolism (dihydropteridine reductase, dihydrofolate reductase) unaffected. The data indicate that H 4biopterin synthesis is individually regulated in the diverse cellular components of the immune system.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
1991
HGF-reported in Year
0
ISSN (print) / ISBN
0006-291X
e-ISSN
1090-2104
Quellenangaben
Volume: 176,
Issue: 3,
Pages: 1430-1436
Publisher
Elsevier
Reviewing status
Peer reviewed
Scopus ID
0025915775
Erfassungsdatum
1991-12-31