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Open Access Green as soon as Postprint is submitted to ZB.
Murine γE-crystallin is distinct from murine γ2-crystallin.
Gene 104, 265-270 (1991)
The murine γE-crystallin-encoding gene (γE-cry) was isolated from a genomic DNA library. The nucleotide (nt) sequence was determined of 1100 bp upstream from the first exon to the polyadenylation site, comprising more than 3600 bp. The gene was characterized by phylogenetic nt sequence analysis in context with the already described γ-cry genes from rat, mouse and human. The γE-cry genes (mouse and rat) are clearly separate from the corresponding γE-cry genes. Based on the phylogeny, the discussion about the murine γ2-cry classification as γF-cry [Bloemendal et al., Exp. Eye Res. 48 (1989) 465-466] is resolved. The murine γE-cry gene has characteristics similar to other genes from the γ-cry gene family, except for an 18-fold repeat of the sequence, 5'-CTCAG, located at the 3'-end of intron B. There is no similar repeat structure in any other γ-cry gene. No binding site for a common transcription factor could be detected among the 1100 bp of the 5'-region.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
γ-crystallin ; 5'-regulatory Elements ; Evolution ; Genomic Dna Library ; Open Reading Frame ; Repeated Sequence ; Sequence Analysis
ISSN (print) / ISBN
0378-1119
e-ISSN
1879-0038
Journal
Gene
Quellenangaben
Volume: 104,
Issue: 2,
Pages: 265-270
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institut für Säugetiergenetik