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Open Access Green as soon as Postprint is submitted to ZB.
Analysis of the crossover design in the presence of residual effects.
Stat. Med. 10, 891-899 (1991)
When a residual effect is suspected in a two-period crossover trial, an analysis of the first-period data is often chosen instead of the potentially biased crossover analysis. This paper indicates how the usual crossover test has to be interpreted correctly and that its bias has two different consequences, namely a conservative or a liberal test decision if a positive (carryover) or a negative (withdrawal) residual effect exists. A multiple testing procedure is presented allowing for simultaneous crossover and first-period analysis controlling the experimental error rate. This procedure together with the correct interpretation of the crossover test enables many useful applications of crossover designs.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0277-6715
e-ISSN
1097-0258
Journal
Statistics in Medicine
Quellenangaben
Volume: 10,
Issue: 6,
Pages: 891-899
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed