PuSH - Publication Server of Helmholtz Zentrum München: Immunological characterization of canine hematopoietic progenitor cells.

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Hahn, J. ; Kolb, H.J. ; Schumm, M.A. ; Beißer, K. ; Ellwart, J.W. ; Rieber, P.* ; Maldacker, J. ; Schwella, N. ; Lösslein, L.K. ; Holler., E. ; Wilmanns, W. ; Thierfelder, S.S.

Immunological characterization of canine hematopoietic progenitor cells.

Ann. Hematol. 63, 223-226 (1991)

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Canine hematopoietic progenitor cells were characterized by separation with monoclonal antibodies. Depleted and enriched fractions were studied for growth of CFU-GM in semisolid agar and for repopulating capacity of lethally irradiated dogs. CFU growth was not reduced by depletion of marrow using monoclonal antibodies F 3-20-7 (anti-dog Thy-1), MT606 (anti-human CD6), and IOT2a (anti-human DR). CFU growth was variable following treatment with the anti-canine T-cell antibody MdT-P1 and immunomagnetic bead separation. It was regularly enriched when MdT-P1 treatment was followed by immunorosetting with staphylococcal protein A-loaded sheep red blood cells and density gradient separation. Lethally irradiated dogs were reconstituted by autologous marrow depleted of MdT-P1-positive cells using immunorosetting and density gradient centrifugation, whereas immunomagnetic bead-depleted marrow was ineffective. Fluorescence-activated cell sorting showed enrichment of hematopoietic progenitor cells in the weakly MdT-P1-positive fraction.

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