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Open Access Green as soon as Postprint is submitted to ZB.
Immunoglobulin heavy-chain joining genes in the rat: Comparison with mouse and human.
Gene 102, 261-264 (1991)
We have cloned by the polymerase chain reaction a 2.1-kb fragment carrying heavy-chain joining (J(H)) gene segments and a part of the J(H)-C(μ) intron of the rat. Sequencing showed that the rat genome has four functional J(H) segments and that only a slight divergence has occurred after the separation of rat and mouse. A systematic sequence comparison between the two species and human revealed an additional J(H) pseudogene in rat and mouse 5' of J(H)1 which has not been described so far. The implications in evolutionary terms are discussed. In addition, we give an assessment of the misincorporation rate of the Taq polymerase.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
J Gene Segments ; Louvain Rat ; Nucleotide Sequence ; Polymerase Chain Reaction ; Pseudogene ; Recombinant Dna
ISSN (print) / ISBN
0378-1119
e-ISSN
1879-0038
Journal
Gene
Quellenangaben
Volume: 102,
Issue: 2,
Pages: 261-264
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institut für Immunologie