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Open Access Green as soon as Postprint is submitted to ZB.
Isolation of a cathepsin B-encoding cDNA from murine osteogenic cells.
Gene 103, 259-261 (1991)
Cathepsin B-encoding cDNA (CTSB) clones have been isolated from a λgt10 library of a murine osteosarcoma by differential screening during a search for genes which are typically expressed during osteogenic differentiation in mouse mandibular condyles in vitro. Sequencing of the CTSB 3' end revealed that the isolated sequence contained an 825-bp 3'-noncoding region, the polyadenylation signal and the poly(A) tail. The enhanced CTSB expression during the early stages of the enchondral ossification-like process in mandibular condyles in vitro suggests that CTSB participates in the degradation of cartilage matrix prior to the synthesis of bone matrix proteins.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
3' End ; Cdna Sequence ; Cysteine Proteinase ; Gene Expression ; Mouse Mandibular Condyles ; Osteogenic Differentiation
ISSN (print) / ISBN
0378-1119
e-ISSN
1879-0038
Journal
Gene
Quellenangaben
Volume: 103,
Issue: 2,
Pages: 259-261
Publisher
Elsevier
Reviewing status
Peer reviewed