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Ehling, U.H. ; Neuhäuser-Klaus, A.

Induction of specific-locus and dominant lethal mutations in male mice by busulfan.

Mutat. Res. -Fund. Mol. Mech. Mutag. 249, 285-292 (1991)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
The chemotherapeutic agent busulfan was tested for the induction of dominant lethal and specific-locus mutations in male mice. A dose of 5 mg/kg b.w. of busulfan induces dominant lethal mutations in spermatozoa. A dose of 20 mg/kg b.w. induces dominant lethal mutations in spermatozoa and spermatids. A total of 83,196 offspring were scored in the specific-locus experiments. Busulfan-induced specific-locus mutations were recovered in spermatozoa and spermatids, but not in spermatogonia. The sensitivity patterns for the induction of dominant lethal and specific-locus mutations by busulfan in germ cells of male mice are similar but not identical.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Busulfan ; Dominant Lethal Mutations ; Male Mouse ; Specific-locus Mutations
ISSN (print) / ISBN 0027-5107
e-ISSN 1873-135X
Journal Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis
Quellenangaben Volume: 249, Issue: 2, Pages: 285-292 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)