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Open Access Green as soon as Postprint is submitted to ZB.
Ascorbate autoxidation in the presence of iron and copper chelates.
Free Radic. Res. 1, 349-353 (1986)
Chelates can inhibit the iron- and copper-catalyzed autoxidation of ascorbate at pH 7.0. Diethylenetri-aminepentaacetic acid (DTPA or DETAPAC) and Desferal (deferoximane mesylate) slow the iron-catalyzed oxidation of ascorbate as effectively as reducing the trace levels of contaminating iron in buffers with Chelex resin. DETAPAC, EDTA and HEDTA (N-(2-hydroxyethyl)-ethylenediaminetriacetic acid) are effective at slowing the copper-catalyzed autoxidation of ascorbate while Desferal is ineffective. The ability to inhibit ascorbate autoxidation appears to parallel the rate of the reaction of superoxide with the iron chelate.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Ascorbate ; Autoxidation ; Copper Chelates ; Iron Chelates
ISSN (print) / ISBN
1071-5762
e-ISSN
1029-2470
Journal
Free Radical Research
Quellenangaben
Volume: 1,
Issue: 6,
Pages: 349-353
Publisher
Taylor & Francis
Reviewing status
Peer reviewed
Institute(s)
Abteilung für Strahlenbiologie und Biophysik