PuSH - Publication Server of Helmholtz Zentrum München: Retrovirus-induced osteopetrosis in mice : Ultrastructural evidence of early virus production in osteoblasts and osteocytes.

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Murray, A.B. ; Schmid, J. ; Rieke, L.

Retrovirus-induced osteopetrosis in mice : Ultrastructural evidence of early virus production in osteoblasts and osteocytes.

Am. J. Pathol. 124, 319-323 (1986)

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Open Access Green as soon as Postprint is submitted to ZB.

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Newborn female strain NMRI mice were given injections of a mouse retrovirus (OA MuLV) known to induce osteopetrosis, osteoma, and lymphoma. Femur metaphyses and lumbar vertebrae were investigated ultrastructurally 3 d, 7 d and 28 d after infection. Budding, immature and mature virus was observed associated with osteoblasts and osteocytes, but not with osteoclasts or chondrocytes, 28 d after infection with the virus. No production of virus particles was observed in bone-tissue in mock-treated controls. Thus, the primary target cell for OA virus in bone appears to belong to the osteoblastic/osteocytic cell lineage.

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Publication type Article: Journal article

Document type Scientific Article

ISSN (print) / ISBN 0002-9440

e-ISSN 1525-2191

Journal American Journal of Pathology, The

Quellenangaben Volume: 124, Issue: 2, Pages: 319-323

Publisher Elsevier

Reviewing status Peer reviewed

Institute(s) Institute of Pathology (PATH)