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Open Access Green as soon as Postprint is submitted to ZB.
Anatomical distribution of CALL antigen expressing cells in normal lymphatic tissue and in lymphomas.
Leuk. Res. 6, 761-767 (1982)
Anatomical distribution of common acute lymphoblastic leukemia antigen (CALLA) was studied in lymphomas as well as in normal lymphatic organs using the monoclonal antibody VIL-A1. Twelve lymphomas were labelled by VIL-A1. Three of the 12 tumours also had T-cell marker, six lymphomas also showed immunoglobulin staining and only three tumours were pure CALLA lymphomas. Tonsils showed a distinct CALLA labelling of many germinal centre cells and of singular cells in interfollicular T-cell regions. Children's thymuses showed rare distinctly labelled cells in the cortex and medulla and slightly more cortical cells stained faintly by VIL-A1. Foetal thymuses of about the twelfth week of gestation contained many heavily labelled cells. The findings are discussed as evidence for the presence of CALLA on immature B as well as T lymphocytes. They favour the idea of CALLA as a common lymphocyte differentiation antigen although other possibilities of interpretation are also discussed.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
CALLA; lymphomas; thymus; tonsil; immunohistochemistry
ISSN (print) / ISBN
0145-2126
e-ISSN
1873-5835
Journal
Leukemia Research
Quellenangaben
Volume: 6,
Issue: 6,
Pages: 761-767
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institut für Hämatologie