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Ballhorn, L. ; Rozman, T.A. ; Rozman, K.K. ; Korte, F. ; Greim, H.A.

Cholestyramine enhances fecal elimination of pentachlorophenol in rhesus monkeys.

Chemosphere 10, 877-888 (1981)
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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
The effect of cholestyramine in the daily diet upon the excretion of pentachlorophenol with the feces was studied in the rhesus monkey. The treatment increased fecal elimination of pentachlorophenol and/or metabolites up to 9- to 14-fold over a six-day period. At the same time urinary excretion was reduced 2- to 6-fold. The data suggest that cholestyramine interrupts the enterhepatic circulation of PCP and/or metabolites thus indicating its possible usefulness in preventing toxicity of PCP that otherwise may occur due to reabsorption of biliary PCP and/or metabolites.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 1981
HGF-reported in Year 0
ISSN (print) / ISBN 0045-6535
e-ISSN 1879-1298
Journal Chemosphere
Quellenangaben Volume: 10, Issue: 8, Pages: 877-888 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Kidlington, Oxford
Reviewing status Peer reviewed
Institute(s) Institute of Ecological Chemistry (IOEC)
DOI 10.1016/0045-6535(81)90087-4
Scopus ID 0019822049
Erfassungsdatum 1981-12-31
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