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Erfle, V.F. ; Hehlmann, R. ; Schetters, H. ; Meier, A.* ; Luz, A.*

Time course of c-type retrovirus expression in mice submitted to osteosarcomagenic doses of 224radium.

Int. J. Cancer 26, 107-113 (1980)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Virus particles with the biochemical properties of C-type retroviruses appeared transiently in bone tissues of (C3H x 101)F 1 hybrid mice early after treatment with 224Radium; such particles were then again detected in the bones of the irradiated animals at the onset of osteosarcoma formation and in the osteosarcomas. Antibodies against a murine retrovirus isolated from a 224Ra-induced osteosarcoma were produced and detected in the serum of the 224Ra-treated animals within a month after treatment began. The antibody levels plateaued to a maximum after about 2 months and remained elevated until the tumors started to develop. The antibody concentration in the serum of these irradiated animals then decreased progressively to reach levels similar to those observed in untreated controls. It thus appears that the imminence of osteosarcoma development can be predicted by monitoring the anti-C-type virus antibody levels in the serum of the irradiated mice. These experiments also strongly suggest that treatment with 224Radium induces expression of endogenous viruses in the animals.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0020-7136
e-ISSN 1097-0215
Journal International Journal of Cancer
Quellenangaben Volume: 26, Issue: 1, Pages: 107-113 Article Number: , Supplement: ,
Publisher Wiley
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Pathology (PATH)