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Points to consider in assessing and appraising predictive genetic tests.
J. Community Genet. 1, 185-194 (2010)
The use of predictive genetic tests is expanding rapidly. Given limited health care budgets and few national coverage decisions specifically for genetic tests, evidence of benefits and harms is a key requirement in decision making; however, assessing the benefits and harms of genetic tests raises a number of challenging issues. Frequently, evidence of medical benefits and harms is limited due to practical and ethical limitations of conducting meaningful clinical trials. Also, clinical endpoints frequently do not capture the benefit appropriately because the main purpose of many genetic tests is personal utility of knowing the test results, and costs of the tests and counseling can be insufficient indicators of the total costs of care. This study provides an overview of points to consider for the assessment of benefits and harms from genetic tests in an ethically and economically reflected manner. We discuss whether genetic tests are sufficiently exceptional to warrant exceptional methods for assessment and appraisal.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Resource allocation; Genetic testing;
Costs and cost analysis
ISSN (print) / ISBN
1868-310X
e-ISSN
1868-6001
Journal
Journal of Community Genetics
Quellenangaben
Volume: 1,
Issue: 4,
Pages: 185-194
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed