PuSH - Publication Server of Helmholtz Zentrum München: Taurolithocholate inhibits taurocholate uptake by isolated hepatocytes at low concentrations.

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Schwenk, M. ; Schwarz, L.R. ; Greim, H.A.

Taurolithocholate inhibits taurocholate uptake by isolated hepatocytes at low concentrations.

Naunyn-Schmiedebergs Arch. Pharmakol. 298, 175-179 (1977)

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The cholestatic bile acid taurolithocholate inhibits taurocholate uptake by isolated liver cells non-competitively. Inhibition is instantaneous and inversely related to the cell number in the incubate. The Kiamounts to 7 μM in the presence of 2 mg cellular protein per ml. Secretion of taurocholate by isolated liver cells is not affected by taurolithocholate up to a concentration of 50 μM. This indicates a difference between the carrier for taurocholate uptake and the carrier for taurocholate secretion. Inhibition of bile acid uptake by liver cells may be involved in the pathogenesis of lithocholate-induced cholestasis.

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