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Open Access Green as soon as Postprint is submitted to ZB.
Taurolithocholate inhibits taurocholate uptake by isolated hepatocytes at low concentrations.
Naunyn-Schmiedebergs Arch. Pharmakol. 298, 175-179 (1977)
The cholestatic bile acid taurolithocholate inhibits taurocholate uptake by isolated liver cells non-competitively. Inhibition is instantaneous and inversely related to the cell number in the incubate. The Kiamounts to 7 μM in the presence of 2 mg cellular protein per ml. Secretion of taurocholate by isolated liver cells is not affected by taurolithocholate up to a concentration of 50 μM. This indicates a difference between the carrier for taurocholate uptake and the carrier for taurocholate secretion. Inhibition of bile acid uptake by liver cells may be involved in the pathogenesis of lithocholate-induced cholestasis.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cholestasis ; Isolated Hepatocytes ; Taurocholate ; Taurolithocholate ; Transport
ISSN (print) / ISBN
0028-1298
e-ISSN
1432-1912
Quellenangaben
Volume: 298,
Issue: 2,
Pages: 175-179
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institut für Toxikologie und Biochemie