PuSH - Publication Server of Helmholtz Zentrum München: Interaction of the insecticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane with the β-receptor adenylate cyclase system in Chang liver cell membranes.

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Buff, K. ; Bründl, A. ; Berndt, J.

Interaction of the insecticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane with the β-receptor adenylate cyclase system in Chang liver cell membranes.

Chem. Biol. Interact. 47, 337-346 (1983)

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Interaction of the insecticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) with β-receptor binding and adenylate cyclase activity of biological membranes has been studied. Following exposure of cultured Chang liver cells to DDT, maximal binding of the catecholamine antagonist [125I]-iodohydroxybenzylpindol (HYP) to isolated cell membranes was decreased by 30% whereas the dissociation constant remained unchanged. Both basal activity and maximal isoproterenol-stimulated activity of adenylate cyclase were not altered. The isoproterenol concentration required for half-maximal stimulation of the enzyme was increased about 2-fold as was the agonist concentration required for half-maximal displacement of the antagonist HYP at the β-receptor binding site. Thus, coupling efficiency of hormone-stimulated adenylate cyclase activity was not influenced by the presence of DDT in these membranes. The data show that interaction of DDT with the β-receptor adenylate cyclase complex is restricted to the receptor component. Enzyme activity is directly linked to changes of agonist binding at the β-receptor. Interference of DDT with signal transuction via 'fluidization' of membrane lipids has not been detected.

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