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Greenwood, A.D. ; Engelbrecht, C.C. ; MacPhee, R.D.E.*

Characterization of an endogenous retrovirus class in elephants and their relatives.

BMC Evol. Biol. 4:38 (2004)
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BACKGROUND: Endogenous retrovirus-like elements (ERV-Ls, primed with tRNA leucine) are a diverse group of reiterated sequences related to foamy viruses and widely distributed among mammals. As shown in previous investigations, in many primates and rodents this class of elements has remained transpositionally active, as reflected by increased copy number and high sequence diversity within and among taxa. RESULTS: Here we examine whether proviral-like sequences may be suitable molecular probes for investigating the phylogeny of groups known to have high element diversity. As a test we characterized ERV-Ls occurring in a sample of extant members of superorder Uranotheria (Asian and African elephants, manatees, and hyraxes). The ERV-L complement in this group is even more diverse than previously suspected, and there is sequence evidence for active expansion, particularly in elephantids. Many of the elements characterized have protein coding potential suggestive of activity. CONCLUSIONS: In general, the evidence supports the hypothesis that the complement had a single origin within basal Uranotheria.
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Publication type Article: Journal article
Document type Scientific Article
Keywords MAMMALS; ELEMENTS; PHYLOGENIES; EVOLUTION; PROTEIN; FAMILY
Language english
Publication Year 2004
HGF-reported in Year 2004
e-ISSN 1471-2148
Journal BMC Evolutionary Biology
Quellenangaben Volume: 4, Issue: , Pages: , Article Number: 38 Supplement: ,
Publisher BioMed Central
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)
Institute of Virology (VIRO)
POF-Topic(s) 30505 - New Technologies for Biomedical Discoveries
30203 - Molecular Targets and Therapies
Research field(s) Enabling and Novel Technologies
Immune Response and Infection
PSP Element(s) G-503700-001
G-502700-001
PubMed ID 15476555
DOI 10.1186/1471-2148-4-38
WOS ID 000226140100001
Scopus ID 8744228083
Erfassungsdatum 2004-12-31
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