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Characterization of an endogenous retrovirus class in elephants and their relatives.
BMC Evol. Biol. 4:38 (2004)
BACKGROUND: Endogenous retrovirus-like elements (ERV-Ls, primed with tRNA leucine) are a diverse group of reiterated sequences related to foamy viruses and widely distributed among mammals. As shown in previous investigations, in many primates and rodents this class of elements has remained transpositionally active, as reflected by increased copy number and high sequence diversity within and among taxa. RESULTS: Here we examine whether proviral-like sequences may be suitable molecular probes for investigating the phylogeny of groups known to have high element diversity. As a test we characterized ERV-Ls occurring in a sample of extant members of superorder Uranotheria (Asian and African elephants, manatees, and hyraxes). The ERV-L complement in this group is even more diverse than previously suspected, and there is sequence evidence for active expansion, particularly in elephantids. Many of the elements characterized have protein coding potential suggestive of activity. CONCLUSIONS: In general, the evidence supports the hypothesis that the complement had a single origin within basal Uranotheria.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
MAMMALS; ELEMENTS; PHYLOGENIES; EVOLUTION; PROTEIN; FAMILY
e-ISSN
1471-2148
Journal
BMC Evolutionary Biology
Quellenangaben
Volume: 4,
Article Number: 38
Publisher
BioMed Central
Non-patent literature
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Reviewing status
Peer reviewed