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Open Access Green as soon as Postprint is submitted to ZB.
Intercomparison of regional deposition of aerosol particles in the human respiratory tract and their long-term elimination.
Exp. Lung Res. 2, 131-139 (1981)
Human chest clearance of Teflon particles with an aerodynamic diameter of 4.7 μm tagged with 198Au or 111In was studied with two exposure apparatuses and two gamma-ray spectrometers for the external detection of the activity deposited in the respiratory tract. Approximately the same chest retention function was measured with two gamma-ray spectrometers when the subjects inhaled equal aerosols under equal breathing conditions. The long-term clearance rate following the short-term elimination of particles from ciliated airways was slower for Teflon particles (mean half-time 105 days for 111In-labeled particles and 128 days for 198Au-labeled particles) than for iron oxide particles of the same size (mean half-time about 60 days). It is suggested that insoluble particles of the size studied are cleared with a half-time of about 120 days within the first 2 weeks after completion of mucociliary clearance. Regional deposition did not differ between the iron oxide and Teflon particles.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0190-2148
e-ISSN
1521-0499
Journal
Experimental Lung Research
Quellenangaben
Volume: 2,
Issue: 2,
Pages: 131-139
Publisher
Informa Healthcare
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Abteilung Biophysikalische Strahlenforschung