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Wiebel, F.J. ; Singh, J.S.D. ; Schindler, E.M. ; Summer, K.H.

UDP-glucuronosyl-, phenol sulfo-, and glutathione-S-transferase activities of mammalian cells in permanent culture.

Toxicology 17, 123-126 (1980)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Established cell cultures derived from mouse, rat, hamster, cat, and man were examined for the in vitro activities of UDP-glucuronosyl-, phenol sulfo-, and glutathione-S-transferases. The relative activities of the conjugation reactions differed considerably between the various cell lines: Glutathione-S-transferase activities were present in all cell lines with wide variation between different transferase forms. Phenol sulfotransferase was not detectable at all in most of the cell lines tested or was present at very low levels. In contrast, UDP-glucuronosyltransferase activity was expressed in the majority of cultures. Established cultures containing specific combinations of the various types of conjugases should be useful in examining their role in the inactivation and activation of potentially toxic chemicals.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0300-483X
e-ISSN 0300-483X
Journal Toxicology
Quellenangaben Volume: 17, Issue: 2, Pages: 123-126 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institut für Toxikologie und Biochemie