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Open Access Green as soon as Postprint is submitted to ZB.
Structural modification of human erythrocyte membranes following gamma-irradiation.
Int. J. Radiat. Biol. 38, 147-158 (1980)
Structural damage to isolated erythrocyte membranes (ghosts has been studied following gamma-irradiation under a variety of conditions. For this two fluorescent probes were used; one 1-anilino-8-naphthalene sulphonate probes the lipid-aqueous interface, the other, diphenylhexatriene, was used to probe the membrane fluidity. Irradiation of the membranes caused a decrease in fluorescent intensity of the added probes, and changes in polarization of fluorescence. Oxygen was found to enhance the radiation damage, and scavenger experiments showed the hydroxyl radical was the major radical species involved. The structural modifications are therefore interpreted in terms of preliminary chemical damage involving peroxidation of unsaturated lipids. In addition sensitization and protection was observed in the presence of known dose-modifying chemicals.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0955-3002
e-ISSN
1362-3095
Quellenangaben
Volume: 38,
Issue: 2,
Pages: 147-158
Publisher
Informa Healthcare
Reviewing status
Peer reviewed
Institute(s)
Abteilung Biophysikalische Strahlenforschung