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Godleski, J.J.* ; Kreyling, W.G. ; Schumann, G.

Particle redistribution in the lungs and short term clearance after multiple inhalations.

J. Aerosol Sci. 21, S487-S490 (1990)

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Brief sequential exposures of dogs to monodisperse, differently labelled aerosol particles of the same aerodynamic size can be used to study particle deposition, redistribution, and short term (14 days) clearance. Since the aerosols have the same aerodynamic size distribution (1.8 - 1.9 μm), the deposition pattern is the same for similar breathing patterns and, hence, the observed patterns of distribution at sacrifice indicate particle redistribution depending on the time of retention. We exposed four beagle dogs to 57Co3O4 aerosols 14 days before sacrifice. Three days before sacrifice, two dogs inhaled 67Ga2O3 particles. Immediately before sacrifice, the two other dogs received 67Ga2O3 particles. The initial 67Ga2O3 pattern showed deposition in airways and uniform parenchymal distribution. The 3 day pattern of retained 67Ga2O3 showed a striking redistribution to pleural and perivascular sites of accumulation with little evidence of airway surface retention. The 14 day pattern of retained 57Co3O4 was similar to the 3 day pattern but more pronounced in its irregular distribution. Quantification of the radiographic distribution patterns by image analysis confirmed the visual observations. We conclude that sequential aerosol exposures can be used to define and quantify patterns of pulmonary redistribution of inhaled particles.

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