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Open Access Green as soon as Postprint is submitted to ZB.
Gene expression during osteogenic differentiation in mandibular condyles in vitro.
J. Cell Biol. 110, 1369-1378 (1990)
The cartilagenous tissue of mandibular condyles of newborn mice contains progenitor cells as well as young and mature chondrogenic cells. During in vitro cultivation of the tissue, progenitor cells undergo osteogenic differentiation and form new bone (Silberman, M., D. Lewison, H. Gonen, M.A. Lizarbe, and K. von der Mark, 1983. Anat. Rec. 206: 373-383). We have studied the expression of genes that typify osteogenic differentiation in mandibular condyles during in vitro cultivation. RNAs of the genes for collagen type I, osteonectin, alkaline phosphatase, and bone gla protein were sequentially expressed in progenitor cells and hypertrophic chondrocytes during culture. Osteopontin expression peaked in both the early and the late phase of the differentiation process. The data indicate a distinct sequence of expression of osteoblast-specific genes during osteogenic differentiation and new bone formation in mandibular condyles.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0021-9525
e-ISSN
1540-8140
Journal
Journal of Cell Biology, The
Quellenangaben
Volume: 110,
Issue: 4,
Pages: 1369-1378
Publisher
Rockefeller University Press
Reviewing status
Peer reviewed
Institute(s)
Abteilung für molekulare Zellpathologie