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SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease.
Lipids 43, 289-299 (2008)
Polymorphisms of the human Delta-5 (FADS1) and Delta-6 (FADS2) desaturase genes have been recently described to be associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids. We have genotyped 13 single nucleotide polymorphisms (SNPs) located on the FADS1-FADS2-FADS3 gene cluster (chromosome 11q12-13.1) in 658 Italian adults (78% males; mean age 59.7 +/- 11.1 years) participating in the Verona Heart Project. Polymorphisms and statistically inferred haplotypes showed a strong association with arachidonic acid (C20:4n-6) levels in serum phospholipids and in erythrocyte cell membranes (rs174545 adjusted P value for multiple tests, P < 0.0001 and P < 0.0001, respectively). Other significant associations were observed for linoleic (C18:2n-6), alpha-linolenic (C18:3n-3) and eicosadienoic (C20:2n-6) acids. Minor allele homozygotes and heterozygotes were associated to higher levels of linoleic, alpha-linolenic, eicosadienoic and lower levels of arachidonic acid. No significant association was observed for stearidonic (C18:4n-3), eicosapentaenoic (C20:5n-3) and docosahexaenoic (C22:6n-3) acids levels. The observed strong association of FADS gene polymorphisms with the levels of arachidonic acid, which is a precursor of molecules involved in inflammation and immunity processes, suggests that SNPs of the FADS1 and FADS2 gene region are worth studying in diseases related to inflammatory conditions or alterations in the concentration of PUFAs.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Fatty acid metabolism; Fatty acids; Genetics; Metabolism; Miscellaneous desaturases; n-6/n-3 fatty acids; Specific lipids
Language
english
Publication Year
2008
HGF-reported in Year
2008
ISSN (print) / ISBN
0024-4201
e-ISSN
1558-9307
Journal
Lipids
Quellenangaben
Volume: 43,
Issue: 4,
Pages: 289-299
Publisher
Springer
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
PSP Element(s)
G-503900-002
Scopus ID
46149088018
Erfassungsdatum
2008-06-10