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Open Access Green as soon as Postprint is submitted to ZB.
Expression of protooncogenes in murine osteosarcomas.
Int. J. Cancer 38, 67-74 (1986)
The expression of 7 protooncogenes (c-cis, c-abl, c-mos, c-bas, cKi-ras, c-fos, c-myc) was examined in transplants and established cell lines from spontaneous and radiation-induced murine osteosarcomas. The transplant tumors were compared with different tissues, particularly skeletal tissue (sternum), and the osteosarcoma cell lines with fibrosis lines from the same mouse strains. C-sis was expressed above the level of controls in 2 osteosarcomas (TV, Os5). Three osteosarcomas showed over-expression of c-abl (TVK, DOS, Os5), c-bas (DOS, Os5 and V893) and c-fos (TVK, DOS, Os5), and 4 osteosarcomas showed over-expression of c-Ki-ras (TVK, DOS, Os5, Os16) and c-myc (TVK, DOS, TV, Os5). C-mos expression was not observed under the conditions used. One cell line (Os5) showed an altered transcript (1 kb transcript of c-fos). Apart from the relatively frequent increase in expression of the c-myc and c-ras-family, there was no indication that any particular protooncogene or combination of protooncogenes was associated with murine osteosarcomas.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0020-7136
e-ISSN
1097-0215
Journal
International Journal of Cancer
Quellenangaben
Volume: 38,
Issue: 1,
Pages: 67-74
Publisher
Wiley
Reviewing status
Peer reviewed
Institute(s)
Institute of Pathology (PATH)