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Open Access Green as soon as Postprint is submitted to ZB.
Action of tocainide and mexiletine on the excitation threshold of myelinated nerves.
Eur. J. Pharmacol. 141, 225-233 (1987)
The antiarrhythmic drugs tocainide and mexiletine increase the excitation threshold and decrease the Na permeability (P(Na)) in nerves. Hodgkin-Huxley model calculations suggest that the P(Na) decrease is not sufficient to explain the threshold increase at low concentrations (<0.7 mM tocainide; < 0.1 mM mexiletine). On the other hand, a drug action on the membrane surface potential would be consistent with results of recent experiments. To clarify this point electrophysiological experiments on single nerve fibres (Rana esculenta) were carried out. Changes of the threshold interval (difference between membrane and threshold potential; V(m) - V(s)) were measured and compared with the corresponding changes of V(m) and V(s) (V(s) was measured by means of the transition voltage V(Tr)). The quantitatively good agreement between changes of V(m) - V(s) and those of V(Tr) suggests that at low concentrations tocainide and mexiletine decrease nerve excitability by acting mainly on the membrane surface charge. This possibility was supported by an independent electrophoresis experiment with myelin vesicles from the same nerve material.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0014-2999
e-ISSN
0014-2999
Journal
European Journal of Pharmacology
Quellenangaben
Volume: 141,
Issue: 2,
Pages: 225-233
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed