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Iliakis, G.E. ; Nüsse, M.

Aphidicolin promotes repair of potentially lethal damage in irradiated mammalian cells synchronized in S-phase.

Biochem. Biophys. Res. Commun. 104, 1209-1214 (1982)

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Open Access Green as soon as Postprint is submitted to ZB.

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Aphidicolin, an inhibitor of the α-polymerase in mammalian cells, at a concentration of 0.5 μg/ml, is shown to enable cells which are growing exponentially and synchronized in the S-phase of the cell cycle, to repair potentially lethal damage caused by exposure to either x-rays or UV light. The drug holds cells up in the S-phase which may serve to allow time for repair and could prevent fixation of damage which may occur when the cells progress through the cell cycle. The possible involvement of α- and β-polymerase in repair of potentially lethal damage is discussed.

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