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Begum, S. ; Lay, J.P. ; Klein, W. ; Korte, F.

Metabolic conversion of 14C-chloralkylene - 9.

Chemosphere 6, 711-718,720-721,723 (1977)
DOI
Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
14C-Chloralkylene-9 was applied to rats for 35 days (2 ppm/day/animal)2. GC-Mass Spectra indicated oxygenated components of chloralkylene-9 in urine and feces. The urinary metabolites were characterized to be mono-, di- and trihydroxy 2,4′-dichlorobiphenyls. The feces contained mainly those metabolites in which the side chain of mono-, di- and tri-isopropyl 2,4′-dichlorobiphenyl was oxidized. Different metabolic products containing alcoholic, aldehydic and carboxylic side chains were detected. Metabolites with unsaturated side chains were also detected. The GC-Mass spectroscopic analysis of chloroalkylene-9 residue showed the major component consisted of di- and tri-isopropyl 2,4′-dichlorobiphenyl. 2,4′-dichlorobiphenyl and monoisopropyl 2,4′-dichlorobiphenyl were found to comprise a smaller percentage of the total residue. There was also an indication of isomerization of 2,4′-dichlorobiphenyl.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0045-6535
e-ISSN 1879-1298
Journal Chemosphere
Quellenangaben Volume: 6, Issue: 11, Pages: 711-718,720-721,723 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Kidlington, Oxford
Reviewing status Peer reviewed
Institute(s) Institute of Ecological Chemistry (IOEC)