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Open Access Green as soon as Postprint is submitted to ZB.
Response of human tumour xenografts to fractionated X-irradiation.
Radiother. Oncol. 6, 15-27 (1986)
The response of two human tumour xenografts to single dose and fractionated X-rays has been tested using regrowth delay as the assay. The tumours were line transplanted cells from a moderately well-differentiated squamous carcinoma of the tonsillar fossa (XJ) and an undifferentiated carcinoma of the floor of the mouth (XR). Comparison of the dose response curves for single doses in air, clamped, or after misonidazole administration, led to estimates of the hypoxic fraction (∼ 15%) and the sensitizer enhancement ratio (≦1.6). When 5 daily fractions were used, the effect of misonidazole (miso) was lost and reoxygenation appeared to be effective in both tumours. Comparison of single doses and 5 fractions in clamped tumours, and in those sensitized by miso, allowed the sparing effect of fraction to be estimated. When analysed by the linear quadratic model the α/β ratios were found to be in the range of 6.4-9.2 Gy and 6.8-16.0 Gy for the two tumours. These values are in good agreement with murine tumours (assayed in vivo or in vitro), with human tumour cells assayed in vitro, and with analyses of fractionated clinical data for skin cancer.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Fractionated Radiation ; Human Tumour Xenografts ; Misonidazole ; Reoxygenation ; Repair Of Sublethal Damage
ISSN (print) / ISBN
0167-8140
e-ISSN
1879-0887
Journal
Radiotherapy and Oncology
Quellenangaben
Volume: 6,
Issue: 1,
Pages: 15-27
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Abteilung für Strahlenbiologie und Biophysik