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Radiation-induced heart disease in rats.
Int. J. Radiat. Oncol. Biol. Phys. 11, 801-808 (1985)
After local irradiation of the rat heart with X ray doses of over 10 Gy (single doses), animals developed symptoms of radiation-induced heart disease, which at higher doses would lead to fatal cardiac failure. The LD 50 at 1 year was between 15 Gy and 20 Gy. The pericardium and epicardium responded to irradiation with exudative pericarditis after 4 months. Focal myocardial damage was secondary to progressive capillary damage.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Chronic radiation damage; Heart; Capillaries
ISSN (print) / ISBN
0360-3016
e-ISSN
0360-3016
Quellenangaben
Volume: 11,
Issue: 4,
Pages: 801-808
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Abteilung für Strahlenbiologie und Biophysik