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Open Access Green as soon as Postprint is submitted to ZB.
Linkage group HL-A-MLC-Bf (properdin factor B) - The site of the Bf locus at the immunogenetic linkage group on chromosome 6.
Hum. Genet. 27, 173-183 (1975)
Genetic linkage between the HL-A and Bf loci could be confirmed in 43 families with 168 offspring. In 4 families, 5 recombinants out of 82 informative meiotic divisions were observed (r=6.1%). The localisation of the Bf marker system was studied in 3 families with crossovers between HL-A and MLC. From these data the following map order of human chromosome 6 can be proposed: HL-A (1st locus) -HL-A (2nd locus)-MLC-Bf---PGM3. The fact that important components of the classical and alternate pathway of complement activation are governed by genes closely linked with HL-A and MLC loci leads to the proposition to include the Bf system into the Major Histocompatibility Complex in man.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0340-6717
e-ISSN
1432-1203
Journal
Human Genetics
Quellenangaben
Volume: 27,
Issue: 3,
Pages: 173-183
Publisher
Springer
Reviewing status
Peer reviewed
Institute(s)
Institut für Hämatologie