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Herbert, A.* ; Gerry, N.P.* ; McQueen, M.B.* ; Heid, I.M. ; Pfeufer, A. ; Illig, T. ; Wichmann, H.-E. ; Meitinger, T. ; Hunter, D.* ; Hu, F.B.* ; Colditz, G.* ; Hinney, A.* ; Hebebrand, J.* ; Koberwitz, K. ; Zhu, X.F.* ; Cooper, R.* ; Ardlie, K.* ; Lyon, H.* ; Hirschhorn, J.N.* ; Laird, N.M.* ; Lenburg, M.E.* ; Lange, C.* ; Christman, M.F.*

Response to Comments on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity".

Science 315, 187e (2007)
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Open Access Green as soon as Postprint is submitted to ZB.
Identification of genetic variants affecting complex traits such as obesity is confounded by many types of bias, especially when effect sizes are small. Given our findings of a positive association between rs7566605 and body mass index in four out of five separate samples, a false positive finding cannot be ruled out with certainty but seems unlikely. Meta-analyses of multiple large studies will help refine the estimate of the effects of rs7566605 on body mass index.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2007
HGF-reported in Year 2007
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 315, Issue: 5809, Pages: 187e Article Number: , Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Computational Biology (ICB)
Institute of Human Genetics (IHG)
POF-Topic(s) 30202 - Environmental Health
30205 - Bioengineering and Digital Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
Enabling and Novel Technologies
PSP Element(s) G-504000-007
G-503891-001
G-504091-001
G-504000-009
G-500700-001
G-503900-001
DOI 10.1126/science.1129763
Erfassungsdatum 2007-08-07
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