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Wiebel, F.J. ; Hlavica, P. ; Grzeschik -, K.H.

Expression of aromatic polycyclic hydrocarbon-induced monooxygenase (aryl hydrocarbon hydroxylase) in man x mouse hybrids is associated with human chromosome 2.

Hum. Genet. 59, 277-280 (1981)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Polycyclic aromatic hydrocarbon-inducible monooxygenase directed toward the substrate benzo(a)pyrene, i.e., 'aryl hydrocarbon hydroxylase', was monitored in cell hybrids formed from mouse RAG cells and several human fibroblasts lines. In RAG cells no aryl hydrocarbon hydroxylase activity was detectable; however, these cells exhibited relatively high levels of NADPH cytochrome C (P-450) reductase (EC. 1.6.2.4). In 12 hybrids lines, induced aryl hydrocarbon hydroxylase segregated with human chromosome 2. The results indicate that the structural gene of the polycyclic aromatic hydrocarbon-inducible monooxygenase or gene(s) involved in the induction of the enzyme is located on human chromosome 2.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 1981
HGF-reported in Year 0
ISSN (print) / ISBN 0340-6717
e-ISSN 1432-1203
Journal Human Genetics
Quellenangaben Volume: 59, Issue: 4, Pages: 277-280 Article Number: , Supplement: ,
Publisher Springer
Reviewing status Peer reviewed
Institute(s) Institut für Toxikologie und Biochemie
PubMed ID 7333581
DOI 10.1007/BF00295458
Scopus ID 0019785874
Erfassungsdatum 1981-12-30
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