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Müsch, H.R. ; Bornhausen, M. ; Kriegel, H. ; Greim, H.A.

Methylmercury chloride induces learning deficits in prenatally treated Rats.

Arch. Toxicol. 40, 103-108 (1978)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Methylmercury chloride (MMC) was given to pregnant rats on the 6th, 7th, 8th, and 9th day after conception in doses of 0.05 and 2.0 mg/kg/day. The female offspring of these animals were tested 90 days after birth for learning ability using operant conditioning procedures. The rats were kept at 90% of their normal body weight and trained in a lever-box to press a bar in order to obtain a food pellet. Significant differences in the acquisition speed became apparent when the ratio of bar presses to reward was increased in a classical contingency of differential reinforcement of high rates even at MMC-doses of 4 × 0.05 mg/kg. These differences were not found in the general motility level nor in motor coordination.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Learning ; Methylmercury Chloride ; Operant Behaviour ; Prenatal Treatment ; Rats
ISSN (print) / ISBN 0340-5761
e-ISSN 1432-0738
Journal Archives of Toxicology
Quellenangaben Volume: 40, Issue: 2, Pages: 103-108 Article Number: , Supplement: ,
Publisher Springer
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Toxicology and Pharmacology (TOX)
Institute of Radiation Biology (ISB)
Abteilung für Nuklearbiologie