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Open Access Green as soon as Postprint is submitted to ZB.
Über die Bedeutung paranodaler Strukturen für die Impulsregeneration am Ranvier´schen schnurring.
The importance of paranodal structures of the Ranvier node for the impulse regeneration
Z. Naturforsch. C 30, 271-277 (1975)
The site of the pulse regeneration in myelinated nerve is generally assumed to be the unmyelinated part of the axon membrane in the Ranvier node. To check this, a microirradiation technique using laser pulses (λ=347 nm, t=20 ns) was used to produce morphological lesions of about 1 μm diameter in various regions of the Ranvier node. The electrophysiological functions were monitored parallel to the irradiation. Depending on the localization of the lesions two types of changes in these functions were observed: If a definite site in the paranodal myelin sheath was damaged without affecting the axon, an action potential could no longer be elicited, although the resting potential as well as the stationary current voltage behavior remained unchanged. A damage of the axon resulted in a breakdown of membrane potential and resistance. In most of the cases the excitability recovered after spontaneous or current induced restitution of the membrane resting potential and resistance. These observations indicate that structures in the paranodal region are vital for the Na activation and inactivation. The membrane potential and stationary current voltage behavior can be attributed to the axon membrane. A new hypothesis concerning the mechanism of the Na+ activation/inactivation process is suggested.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0939-5075
Quellenangaben
Volume: 30,
Issue: 2,
Pages: 271-277
Publisher
Verl. der Zeitschrift für Naturforschung
Reviewing status
Peer reviewed
Institute(s)
Departments & Institutes