PuSH - Publication Server of Helmholtz Zentrum München: Interpretation of the dose and LET dependence of RBE values for lethal lesions in yeast cells.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Frankenberg, D.

Interpretation of the dose and LET dependence of RBE values for lethal lesions in yeast cells.

Radiat. Res. 97, 329-340 (1984)

Publ. Version/Full Text

DOI

	Licenced for HMGU

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

Survival data on yeast cells proficient or deficient in the repair of DNA double-strand breaks (dsb) and data on the induction of dsb are used to interpret the dose dependence of the RBE value for lethal lesions after irradiation at high dose rate followed by 72-hr liquid holding providing optimum conditions for repair of potentially lethal lesions (RBE(DP), DP = delayed plating). The radiations applied are conventional (150 kV), soft (50 kV), and ultrasoft (4 kV) X rays, 30-MeV electrons (or 60Co γ rays), and 3.5-MeV α particles. Analysis shows that the dose dependence of the RBE(DP) value can be explained by the combination of two dose-independent RBE values, one for the single-particle traversal effect (RBE(spt)) and the other for the accumulation of dsb (RBE(dsb)) due to the traversal of more than one particle through the cell nucleus. Furthermore, it is shown that the LET dependence of RBE(spt) values describing the linear component of the lethal lesions must be considered separately for 'electron' and 'particle' radiations.

Impact Factor

Scopus SNIP

Altmetric

0.000