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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Excretion of β-hexachlorocyclohexane by the rat as influenced by oral paraffin, squalane, and lutrol E 400.
Ecotoxicol. Environ. Saf. 5, 270-280 (1981)
Following the administration of 1.5 ppm β-hexachloro[14C]cyclohexane (β-HCH) for 1 week in the diet, excretion of radioactivity with urine and feces was measured for 8 weeks in 20 male rats. Eight percent light liquid paraffin added to the diet for the whole 8 weeks significantly enhanced the elimination of radioactivity with feces as well as with urine. Whole-body elimination half-lives of the second compartment of a two-compartment model were reduced from 71 to 37 days in paraffin-fed rats. Addition of paraffin to the diet only in the second 4 weeks of the elimination phase also stimulated the excretion of β-HCH. Eight percent Lutrol E 400 added to the diet was as effective as paraffin; 8% squalane added to the diet did not enhance the excretion of β-HCH during the second 4 weeks of the elimination phase. Paraffin and squalane did not affect body weight gain; Lutrol significantly reduced body weight gain in rats.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0147-6513
e-ISSN
0147-6513
Quellenangaben
Volume: 5,
Issue: 3,
Pages: 270-280
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institute of Ecological Chemistry (IOEC)