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Open Access Green as soon as Postprint is submitted to ZB.
Synthesis and interferon-γ controlled release of pteridines during activation of human peripheral blood mononuclear cells.
Biochem. Biophys. Res. Commun. 132, 404-411 (1985)
Lectin stimulation of human peripheral blood mononuclear cells causes an increase in neopterin, biopterin, 6-hydroxymethylpterin and 6-formylpterin, as was determined by HPLC after iodine oxidation of the acid extract. After 72 h, pteridines peak at levels 5-10-fold as compared to resting cells. Levels decline to initial values during the following 24 h. Changes in pteridine proportions indicate that the synthesis of tetrahydrobiopterin proceeding from dihydroneopterin triphosphate is controlled during the process of lymphocyte activation. The release of both cellular neopterin and biopterin, but not of 6-hydroxymethylpterin and its aldehyde, is controlled by interferon-γ.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0006-291X
e-ISSN
1090-2104
Quellenangaben
Volume: 132,
Issue: 1,
Pages: 404-411
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institut für Toxikologie und Biochemie