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Schmahl, W.G. ; Kriegel, H.

Ovary tumors in NMRI mice subjected to fractionated X-irradiation during fetal development.

J. Cancer Res. Clin. Oncol. 98, 65-74 (1980)

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Fractionated X-irradiation of pregnant mice was performed either during late organogenesis (gestational days 11-13), during the early fetal period (g.d. 14-16), or during both periods (g.d. 11-16). The offspring were observed for 39 months. A significant increase of ovary tumor frequency was observed with 3x1.2 Gy, applied either in late organogenesis or in the early fetal period. Lower X-irradiation doses were ineffective in these periods with respect to ovary tumor development. A sharp increase in ovary tumor frequency resulted after irradiation with 6x0.8 Gy or 6x1.2 Gy. The highest incidence of ovary cysts was observed after 3x1.0 Gy or 3x1.2 Gy on g.d. 11-13, while the frequency of these cysts was lowest in the animals irradiated six times, which, however, showed a high ovary tumor frequency. Autoradiography of the fetal ovaries either 1 or 6 days after irradiation at the late organogenesis stage revealed a persistent depression of this organ's proliferation rate throughout pregnancy. This may be consistent with the low tumor inducibility after X-irradiation in this period.

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