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Cartilaginous metaplasia and overgrowth of neurocranium skull after X-irradiation in utero.
Virchows Arch. 384, 173-184 (1979)
Prenatal X-irradiation of mice in the late organogenesis stage either with a fractionated or a single exposure dose (3 × 160 R or 200 R) leads to remarkable, previously undescribed malformations of the skull. These malformations range from mild hyperostotic nodule formation in about 90% of the offspring to excessive formation of desmal bony tissues, which extend deep into the forebrain and are thus only detectable in histological sections. Metaplastic and hyperplastic formation of cartilage in all the neurocranial regions is observed in about 10% of the offspring. The pathogenesis of these overgrowth phenomena is presumably related to a growth disturbance of both the mesenchymal skull primordium and the brain. While malformation of the latter leads to a decrease of intracranial pressure and consequently to altered growth activity of the skull sutures, the reparative and proliferative capacities of the mesenchyme are also stimulated, in a hyperplastic direction, by X-irradiation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
In Utero ; Overgrowth ; X-irradiation
ISSN (print) / ISBN
0042-6423
e-ISSN
1432-2307
Journal
Virchows Archiv
Quellenangaben
Volume: 384,
Issue: 2,
Pages: 173-184
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Abteilung für Nuklearbiologie