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Open Access Green as soon as Postprint is submitted to ZB.
Effects of hyperthermic conditions on the reactivity of oxygen radicals.
Free Radic. Res. 2, 7-18 (1986)
Generation and reactivity of superoxide (02 -) and hydroxyl (OH') radicals in enzymatic and radiolytic systems were investigated over the temperature range from 20o-50oC. The generation rate and reaction kinetics of both enzymatically and radiolytically produced superoxide radicals were determined by a cytochrome c reduction assay. For OH' radical reaction studies the degradation of hyaluronic acid was assayed. An increase in temperature leads to a greater reactivity of both radicals, but in the case of an enzymatic source a disproportionate increase in the rate of generation is observed. In the pulse radiolysis system, the reactivity of superoxide radicals was found to be stimulated 15-fold over the temperature range from 20oC to 60oC, although the activity of superoxide dismutase was only minimally increased (about 1.6-fold). The results are discussed with respect to the possible importance of active oxygen species to the biological effects of hyperthermia.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Hyaluronic Acid Degradation ; Hydroxyl Radicals ; Hyperthermia ; Oxygen Activation ; Superoxide Radicals
ISSN (print) / ISBN
1071-5762
e-ISSN
1029-2470
Journal
Free Radical Research
Quellenangaben
Volume: 2,
Issue: 1-2,
Pages: 7-18
Publisher
Taylor & Francis
Reviewing status
Peer reviewed
Institute(s)
Institut für Hämatologie